Main areas of research:

Viral protein interaction networks: We have studied the protein interaction networks of human herpesviruses and their interactions with human protein networks (Uetz et al. 2006). Currently we are expanding this project by comparing interaction networks and their interactions with more extensive screens of human libraries.

Bacterial interaction networks: After having analyzed the protein interaction network of the Syphilis spirochete Treponema pallidum (e.g. Rajagopala et al. 2007), we are now investigating the networks of other species such as Streptococcus pneumoniae and Francisella tularensis.

Bioinformatics of protein interactions: Although bioinformatics analyses play a major role in all of the aforementioned projects they are pursued in their own right. For example, we have analyzed protein interaction data from other groups (e.g. Goll et al. 2006) and currently establish a database of microbial interactions. The goal of these efforts is a global survey of all protein interactions in bacteria.

Selected publications

Rajagopala S.V., Titz B., Goll J., Parish J., McKevitt M.T., Palzkill T., Finley R.L. Jr. & Uetz P. (2007) The protein network of bacterial motility. Molecular Systems Biology 3: 128

Uetz, P. et al. (2006) Herpesviral Protein Networks and Their Interaction with the Human Proteome. Science 311: 239-242

Goll, J. & Uetz, P. (2006) The elusive yeast interactome. Genome Biology 7 (214): 1-6