General description
- The UvrA family of proteins is composed to two distinct subfamilies
- UvrA1 and UvrA2 (White
et al, 1999)
- The UvrA1 subfamily includes the standard UvrA proteins involved in
the recognition of DNA damage as a step in nucleotide excision repair in
bacteria.
- The UvrA2 subfamily includes proteins with as yet poorly characterized
role in providing resistance to certain antibiotics as well as a few additional
proteins with no known functions.
ABC protein family
- All proteins in the UvrA family are members of the ABC (ATP binding
cassette) superfamily of proteins.
- ABC proteins are primarily involved in transport of molecules in and
out of cells of all species - including bacteria, Archaea, and eukaryotes.
- ABC proteins are primarily known as subunits of ABC transporters. The
ABC transporers are usually composed of two types of domains - transmembrane
spanning domains, through which the molecules are transported and ABC domains
which encode the ATPase activity required to catalyze transport.
- In some ABC transporters the ABC and transmembrane domains are part
of a single protein, in others they are separated.
- Many ABC transporters are composed of two ABC and two transmembrane
domains.
- Proteins in the UvrA family encode only the ABC domain (from 2-3 copies
of this domain) (see Doolittle
et al (1986) )
- For more information on the ABC protein family: